Best NMN + NR Supplements in the US (2026 Buyer's Guide)

We compared nine NAD+ precursor products sold in the US, verified on each brand's own site on October 13, 2026, against six criteria: dose versus the human trials, lot-level testing, form, cost per day, fillers, and serving honesty. Seven made the ranking. Tru Niagen wins on clinical history for NR alone. For a combined NMN + NR capsule with a public lot certificate, our own product takes the top spot, and the math is shown rather than asserted.

Mt. Angel Vitamins makes one of the products ranked below. We manufacture it ourselves in Mt. Angel, Oregon, so we have an interest in where it lands. Here is how we handled that: every product, ours included, was scored on the same six criteria; every competitor fact was read from the brand's own website on October 13, 2026; and where another brand is the better choice for a situation, that brand gets the category. Six of the seven categories below go to products we do not make.

If you only read one thing

For most people: 250 to 500 mg of NMN, or 300 mg of NR chloride, from a product that posts a lot-specific certificate of analysis, at $1.20 to $2.00 a day. Our two-capsule NMN + NR is the pick if you want both precursors in one bottle with the lot test linked on the product page.

If you want the single precursor with the most human-trial history: NR, and Tru Niagen 300 mg is the reference product.

If price per milligram is the whole decision: Renue by Science NMN powder at 27 cents per 500 mg scoop.

Scroll for the picks by situation and the side-by-side table.

Key Takeaways

• A January 2026 trial in Nature Metabolism (Christen et al., 65 adults, 14 days) found NR and NMN raised circulating NAD+ by comparable amounts, and that both are partly converted to nicotinic acid by gut bacteria before absorption. The NMN-versus-NR argument matters less than the marketing suggests.
• The human NMN trials used 250 to 1,200 mg a day. The largest dose-ranging trial (Yi et al., 2022, 80 adults, 60 days) found 600 mg produced the highest blood NAD+ and the longest six-minute walk gains, with 300 mg still effective.
• NR raises whole-blood NAD+ in a dose-dependent way: 22%, 51%, and 142% at 100, 300, and 1,000 mg a day over eight weeks in a 140-person trial (Conze et al., 2019).
• A 2024 GeroScience analysis of NMN and Urolithin A supplements (Sandalova et al.) found actual content ranging from 28.6% over label to 100% under it, meaning some capsules contained no NMN at all. A lot-specific certificate of analysis is the only defense.
• NMN is lawful to sell as a dietary supplement in the US again. FDA reversed its 2022 position in letters dated September 29, 2025.
• Verified cost per day on October 13, 2026 ran from $0.27 (bulk NMN powder) to $2.17 (1,000 mg NMN capsules, or 250 mg NR with pterostilbene). A tested 300 to 500 mg dose should cost $1.20 to $2.00 a day. Above that, you are paying for the brand.

How we judged them

Six criteria, applied the same way to every product, including ours. The order matters. Dose comes first, because a cheap product at a dose no trial has tested is not cheap.

Dose versus the human trials

The number to anchor on is 250 to 600 mg a day for NMN and 300 to 1,000 mg a day for NR. Those are the ranges the placebo-controlled human trials actually used. For NMN: 250 mg a day for 10 to 12 weeks in Yoshino et al. (Science, 2021), Okabe et al. (Frontiers in Nutrition, 2022), and Igarashi et al. (npj Aging, 2022); 300, 600, and 900 mg for 60 days in Yi et al. (GeroScience, 2022); up to 1,200 mg in Liao et al.'s six-week trial in amateur runners (Journal of the International Society of Sports Nutrition, 2021); and 1,000 mg twice daily for 28 days in Pencina et al. (Journal of Clinical Endocrinology and Metabolism, 2023).

For NR: 100, 300, and 1,000 mg for eight weeks in Conze et al. (Scientific Reports, 2019); 500 mg twice daily for six weeks in Martens et al. (Nature Communications, 2018); and 250 mg NR with 50 mg pterostilbene for eight weeks in Dellinger et al. (npj Aging and Mechanisms of Disease, 2017).

A product below 250 mg of NMN or 250 mg of NR per daily serving sits below every trial on that list. The NMN monograph grades each of these studies, and the NMN versus NR comparison covers how the two precursors differ on the way into the cell.

Testing you can actually read

"Third-party tested" on a label is a claim. A certificate of analysis (COA) with a lot number, the lab's name, the method, and the measured result is evidence. Full marks went only where a lot-level COA is linked from the product page or reachable through a batch lookup.

The 2024 GeroScience analysis by Sandalova et al. is why this criterion sits second: NMN and Urolithin A supplements bought online and in pharmacies ranged from 28.6% over label to 100% under it. The same problem runs through our Urolithin A buying guide and the Urolithin A monograph, and our guide to reading a supplement certificate of analysis explains which fields matter.

Form and the salt question

NMN in the trials was β-NMN powder in ordinary capsules or tablets. Sublingual and liposomal versions have brand-run data, but we could not verify an independent placebo-controlled trial of either on PubMed. For NR, the form question is the salt. Every NR trial cited in this guide that names its material used NR chloride, sold as Niagen. Two products below use NR hydrogen malate, and their labels list the weight of the salt rather than the NR inside it. That is not disqualifying. It does mean the milligrams are not directly comparable.

Price per effective day

Price per bottle is noise. We divided the verified price by servings per container, then noted what a serving contains, because 300 mg of NR and 1,000 mg of NMN are not the same purchase. The $35.95 bottle of 90 capsules at three per serving comes to $1.20 a day; the $49.00 bottle of 30 at one per serving comes to $1.63. Where a label allows one or two capsules, we show both numbers.

Fillers and what is not disclosed

Rice flour, cellulose, and a vegetable capsule are fine. A "proprietary blend" that hides the NMN or NR dose is not, and no product in this ranking uses one. We also checked whether the brand names its manufacturer or facility on the product page.

Serving honesty

The oldest trick in the aisle is a labeled dose that takes two or three capsules while the front panel reads as if it were per capsule. We state capsules per serving for every pick. One pick needs three a day.

The picks

Prices, serving counts, doses, and certifications below were read from each brand's own product page on October 13, 2026. They will drift. The criteria will not.

Best Overall NMN + NR Combination: Mt. Angel Vitamins NMN + NR Cellular Wellness

Two capsules deliver 500 mg NMN, 200 mg NR, 250 mg resveratrol, 50 mg TMG, and 10 mg zinc, with BioPerine for absorption. 60 capsules, 30 servings at the full dose, $59.99, or $2.00 a day. The label allows one capsule a day, which stretches the bottle to 60 days at $1.00 and halves every dose.

It won this category for one reason we can show rather than assert: the lot-specific certificate of analysis is linked on the product page, and for lot 0077634 an independent ISO-accredited lab (MS Bioanalytical, Champaign, Illinois) measured 614 mg of NMN per serving against the 500 mg claim, with NR at 245 mg against 200 mg. Heavy-metal and microbial results sit on the same page. We make it in our own cGMP facility in Mt. Angel, Oregon, test every batch in our in-house lab for identity, potency, and purity, and publish the COA by lot; the lab-testing page explains what each test covers.

Where it falls short: $2.00 a day is 80 cents more than the budget combination below, 200 mg of NR is under the lowest dose used alone in the NR trials, and the five-ingredient combination has not been tested as a unit in a human trial. Current price and label, and the evidence behind each ingredient in the stack.

Best Clinically Validated Single Precursor: Tru Niagen 300 mg

One vegetarian capsule, 300 mg Niagen NR chloride. 30 capsules for $49.00 ($1.63 a day) or 90 for $127.00 ($1.41 a day). NSF Certified for Sport, Alkemist Assured, kosher and halal, and the ingredient is GRAS with two New Dietary Ingredient notifications on file.

It wins this category because the trial record for NR is longer than for any other precursor, and most of it used this exact material: Trammell et al. (2016) showed dose-dependent blood NAD+ increases at single doses of 100, 300, and 1,000 mg; Conze et al. (2019) ran 140 overweight adults for eight weeks; Martens et al. (2018) ran a six-week crossover in middle-aged and older adults. The 300 mg dose raised whole-blood NAD+ by about 51% in Conze.

Where it falls short: 300 mg is the low end of the trial range, the price per milligram is the highest of the NR capsules here, and the same ingredient is sold for less by the next pick.

Best Value NR (Same Niagen Ingredient): Life Extension NAD+ Cell Regenerator 300 mg

One vegetarian capsule, 300 mg Niagen NR chloride, 30 capsules, $40.50 ($1.35 a day). Non-GMO, gluten-free, vegetarian.

Niagen is a ChromaDex trademark, as the label states, and it is the same branded ingredient in Tru Niagen, so the trial record above applies to the molecule in this bottle too. That is the whole argument. Identical labeled NR, 28 cents a day less than the 30-count Tru Niagen and 6 cents less than the 90-count.

Where it falls short: no NSF Certified for Sport listing, and the product page did not show a lot-level COA when we checked, so you are trusting the brand's internal testing rather than reading it.

Best Budget NMN + NR Stack: ProHealth Longevity NMNR Pro Synergy

Three capsules deliver 500 mg NMN, 500 mg nicotinamide riboside listed "as NR Hydrogen Malate," and 300 mg TMG. 90 capsules, 30 servings, $35.95, or $1.20 a day. ProHealth posts a COA, states that each batch is tested three times by independent labs, manufactures in FDA-registered, GMP-certified US facilities, and offers a 100-day refund window.

If your decision is milligrams of precursor per dollar, this wins, and it beats our product on that measure by 80 cents a day.

Where it falls short: three capsules a day instead of two; the NR is the hydrogen malate salt, so the 500 mg is the salt weight and the NR content is lower and not stated; and the NR trials in this guide used the chloride form. No resveratrol or zinc, which some buyers want and others are glad to skip.

Best Budget NMN for People Who Hate Pills: Renue by Science NMN Pure Powder

100 grams of β-NMN powder, one 500 mg scoop per serving, 200 servings, $54.95, or 27 cents a serving (55 cents a day at the 1,000 mg many people take).

Vegan, no capsule, and the brand publishes a COA per batch with a batch-number lookup; the currently shipping batch listed potency testing on the page when we checked. The brand states refrigeration is not required if the container stays sealed and dry.

Where it falls short: a scoop is less precise than a capsule, powder meets humid air every time you open it, and the brand's own suggested use (one scoop twice daily) doubles the cost it quotes per serving.

Best High-Dose NMN Capsule: ProHealth Longevity NMN Pro 1000

Two capsules deliver 1,000 mg of Uthever β-NMN, 60 capsules to the bottle, 30 servings, $64.95, or $2.17 a day. Third-party tested, COA available, FDA-registered GMP facility.

This is the pick if you want to match the 900 to 1,000 mg daily doses from Yi et al. (2022) and Pencina et al. (2023) without taking four capsules of a 250 mg product.

Where it falls short: Yi's data put the NAD+ and walking-distance peak at 600 mg, so the extra 400 mg bought little in that trial, and $2.17 a day is the highest price in this ranking. The same brand's 500 mg capsule is $42.95 for 30 ($1.43 a day) if you want the trial-median dose instead.

Best NSF Certified for Sport NR per Dollar: Thorne NiaCel 400

One capsule, 415 mg nicotinamide riboside hydrogen malate plus 85 mg TMG. 60 capsules, $74, or $1.23 a day. NSF Certified for Sport, gluten-free, dairy-free.

For a drug-tested athlete, or anyone who wants the NSF Sport seal, it is the lowest cost per day of the three NSF-certified products we verified (Tru Niagen is $1.41 to $1.63; Elysium Basis is $2.17).

Where it falls short: 415 mg is the weight of the salt, so the NR delivered is less than that and the label does not say how much; this salt is not the form used in the NR trials cited above; and the $74 bottle is the highest upfront price here even though the per-day cost is mid-pack.

Side-by-side

All figures read from each brand's own product page on October 13, 2026.

Also verified, not ranked. Elysium Basis (250 mg NR chloride plus 50 mg pterostilbene per two capsules, 30 servings, $65, $2.17 a day, NSF Certified for Sport) has its own placebo-controlled trial (Dellinger et al., 2017, 120 adults, NAD+ up about 40% at the label dose) and loses only on price, as the most expensive NR per milligram in the set. Renue by Science NMN Liposomal Capsules (500 mg per two capsules, 45 servings, $64.95, $1.44 a day) cost about five times the same brand's powder per milligram on brand-run data. ProHealth NMN Pro 500 (500 mg per capsule, 30 servings, $42.95, $1.43 a day) is the middle option noted under the 1,000 mg pick.

What the human trials show, and what they do not

Evidence grades below use the hub's vocabulary: Strong, Moderate, Preliminary, Insufficient. Each grade is for one outcome, because "NMN works" is not an outcome.

Raising blood NAD+ (NMN): Strong. Every placebo-controlled trial that measured it found an increase: Okabe et al. (2022, 30 adults, 250 mg, 12 weeks), Igarashi et al. (2022, older men, 250 mg, 6 to 12 weeks), Yi et al. (2022, 80 adults, 300 to 900 mg, 60 days), and Pencina et al. (2023, 30 adults, 1,000 mg twice daily, 28 days). Zhang et al.'s 2024 meta-analysis of 12 trials (513 participants) confirmed the NAD+ effect. The limitation: Kuerec et al. (2024), reanalyzing the Yi trial, found the NAD+ response varied between people with a coefficient of variation of 29% to 113%, so a given dose does not produce a given level.

Raising blood NAD+ (NR): Strong. Trammell (2016), Conze (2019), Martens (2018), Dellinger (2017), and Elhassan (2019) all found it, in whole blood, in white blood cells, and in muscle. The Christen et al. 2026 head-to-head (Nature Metabolism, 65 adults, 14 days) found NR and NMN comparable, and found that nicotinamide alone did not sustain the increase.

Walking distance and aerobic capacity (NMN): Moderate. Yi et al. found longer six-minute walks at every NMN dose versus placebo at days 30 and 60. Liao et al. found higher oxygen uptake at ventilatory thresholds in trained runners at 600 and 1,200 mg. Wang et al.'s 2025 meta-analysis (nine trials, 412 participants) found a small gait-speed effect. Against: Akasaka et al. (2022) gave 250 mg for 24 weeks to 14 men over 65 with impaired walking and found no change in grip strength or walking speed. The trials are small, and several were funded by ingredient suppliers.

Insulin sensitivity and blood lipids (NMN and NR): Insufficient, conflicting. Yoshino et al. (2021, Science) found improved muscle insulin sensitivity with 250 mg NMN in 25 postmenopausal women with prediabetes. Yi et al. found no HOMA-IR change at any dose. Zhang's meta-analysis found most clinically relevant outcomes unchanged and wrote that "an exaggeration of the benefits of NMN supplementation may exist in the field." For NR, Dollerup et al. (2018, 2,000 mg a day, 12 weeks, 40 men with obesity) and Remie et al. (2020, 1,000 mg a day, 6 weeks, 13 adults) found no insulin-sensitivity improvement. Pencina found lower cholesterol and body weight with high-dose NMN in a 30-person trial that the authors themselves say needs a larger follow-up.

Lifespan, "biological age," or any disease outcome: Insufficient. No human trial has measured them. The "blood biological age" result in Yi et al. is an algorithm's output, not a clinical outcome.

Short-term tolerability: Strong. None of the trials above reported serious adverse events attributed to the supplement at up to 900 mg of NMN daily for 60 days, 2,000 mg of NMN daily for 28 days, or 2,000 mg of NR daily for 12 weeks. Data past six months do not exist.

Red flags

A dose below every trial

50 or 100 mg of NMN inside a "longevity blend" has no placebo-controlled human data behind it. The lowest NMN dose in any trial cited here is 250 mg. For NR, the lowest dose that moved whole-blood NAD+ in Conze et al. was 100 mg (a 22% rise), and 300 mg is where the clinical products start. Below those numbers you are buying the word, not the molecule.

No lot number, no lab name, no result

"Third-party tested" with nothing to click is the pattern the 2024 Sandalova analysis exists to warn about. A real COA names four things: the lab, the method (HPLC for NMN and NR), the lot, and the measured amount. No COA? Assume the label number is aspirational.

A proprietary blend anywhere near the precursor

A blend weight hides the dose of the one ingredient you are paying for. None of the seven picks does this. Plenty of marketplace listings do.

Salt weight sold as active weight

"415 mg nicotinamide riboside hydrogen malate" is honest if you know what it means and misleading if you read it as 415 mg of NR. Any salt or complex (malate, chloride, "NR complex") should state the amount of the base compound. When it does not, ask the brand, and weigh the answer against the price.

"Clinically proven" with no citation

The phrase is on half the boxes in this category. If the page cannot point to a PubMed record of a trial on that product, or that exact ingredient at that dose, the claim is borrowed from someone else's trial. Two brands in this guide (the maker of Tru Niagen and Elysium) ran placebo-controlled trials on their own material. The rest are borrowing, which is fine when they say so.

Marketplace listings with no manufacturer named

Amazon and other large marketplaces delisted NMN during the 2022 to 2025 dispute over its status, and many of the sellers who filled the gap were unnamed. A listing that does not name the manufacturer and its facility has no one to hold to the label.

Who should skip this entirely

Most people under 40 with a decent diet do not need an NAD+ precursor, and no trial has shown a benefit in that group; the trials recruited middle-aged and older adults. Skip it if you are pregnant or nursing, since no trial included you. Skip it if you take prescription medication and have not asked a pharmacist. Skip it, for now, if you have not covered the basics the trials assumed: adequate protein, regular movement, and nutrients with a far deeper evidence base, starting with your vitamin D status. If what you want is mitochondrial energy support with a longer human track record, CoQ10 has one. And if you cannot find a lot-level COA for the product in your cart, skip that product, whatever the category. The honest version of this market is still small.

Next reads

• How NMN works, dose by dose, with every trial graded: the monograph this guide is built on.
• NMN versus NR: how the two precursors differ on the way into the cell: the comparison page, for the mechanism argument.
• The evidence for each ingredient in an NMN + NR + TMG + resveratrol + zinc stack: why combination products are built the way they are, with a one-page visual summary.

More on NAD+ and Cellular Energy: The Complete Guide