Mitopure vs Mt. Angel Urolithin A: Which Should You Buy?

Same molecule, same 500 mg dose, so the verdict is about fit. Timeline's Mitopure ($3.30 a day) is the material used in every published human trial. Mt. Angel's capsule ($1.50 a day) carries a third-party assay on its raw-material lot. Pay for Mitopure if the trial record on the label matters; otherwise buy the trial dose for less than half.

The verdict

For most people: Mt. Angel Vitamins Urolithin A, 500 mg in one capsule, at $1.50 a day. Same molecule and daily dose as the trials, with an independent assay on the exact raw-material lot. We make this one, so read the rest with that in mind.

When Mitopure wins: when you want the identical material, softgel and all, that produced every published human result, or when you are drug-tested in sport. No other urolithin A product has been through a trial. Timeline wins clinical validation outright.

The fact that decides it: urolithin A is one defined molecule. Mitopure is a trademark for one company's version of it, not a different compound. The extra $1.80 a day buys the trial record and an NSF Certified for Sport mark, not a different ingredient.

If you want the ingredient itself explained first, start with the urolithin A monograph. The urolithin A buying guide ranks five brands and gave Timeline the clinical-validation category there too. This page is the two-way decision: Timeline's Mitopure softgels against the 500 mg capsule we make in Mt. Angel, Oregon. Prices and certifications below were checked on October 14, 2026.

Key Takeaways

• Urolithin A is a single defined molecule (3,8-dihydroxy-6H-dibenzo[b,d]pyran-6-one). Mitopure is Amazentis's trademark for the urolithin A it manufactures and sells through Timeline, not a different compound.
• Every published human trial of urolithin A used Mitopure. The strongest, Singh 2022 in Cell Reports Medicine, randomized 88 adults aged 40 to 64 and found hamstring strength up 12% at 500 mg a day over four months, while the primary endpoint (peak power output) did not reach significance.
• Mitopure costs $99.00 for 30 days (two softgels a day) and Mt. Angel's capsule costs $89.99 for 60 days (one capsule a day): $3.30 versus $1.50 per 500 mg day at list prices on October 14, 2026.
• Timeline carries NSF Certified for Sport: a factory audit, finished-product label-claim and contaminant testing, and a 290-substance banned-list screen on production lots. Mt. Angel publishes a lot-specific certificate showing the exact raw-material lot assayed at 100% urolithin A by an independent laboratory against a 98% minimum.
• No trial has compared a non-Mitopure urolithin A to Mitopure, and no trial has compared a softgel to a hard capsule. The pharmacology argument for equivalence is strong. The trial evidence for it does not exist.
• Only 12% of adults had detectable urolithin A at baseline, and about 40% could make it from a glass of pomegranate juice, in a 100-person study (Singh 2021, European Journal of Clinical Nutrition). Both products exist because of that gap.

Side-by-side

Where they actually differ

Urolithin A is a metabolite, a molecule your gut bacteria make from ellagitannins, the tannins in pomegranate, walnuts, and some berries. Same molecule, whoever bottles it, and whether your own bacteria make any depends on which urolithin metabotype you carry (García-Villalba 2022). What makes it interesting is mitophagy: the process by which a cell tags a worn-out mitochondrion and recycles it. Urolithin A was the first natural compound shown to switch that process on after oral dosing, in worms and rodents (Ryu 2016, Nature Medicine), and the mitophagy research page walks through the PINK1/Parkin pathway it uses. That is a different lever from the NAD+ precursors, NMN and NR, that get grouped with it in longevity stacks.

So what is Mitopure? A registered trademark owned by Amazentis, the Lausanne company that ran the trials. Timeline is Amazentis's consumer brand. The trademark attaches to Amazentis's manufacturing process and, more to the point, to its clinical dossier. When Timeline says Mitopure is clinically validated, that is true in the narrowest and most useful sense: the softgels in the box are the softgels that were in the trials.

The differences that are real, in the order they should matter to you:

The trial record. Every human trial on PubMed used Mitopure. That is not a tie. Timeline can point at a box and a paper and say "this, exactly." We can point at the same papers and say "this molecule, at this dose," which is a weaker claim, and we should say so.

The format. Two softgels against one hard capsule, and the trials dosed those softgels on an empty stomach before breakfast. Nobody has published a softgel-versus-capsule absorption comparison for urolithin A. Oral urolithin A was absorbed at every dose tested in the first-in-human trial (Andreux 2019), so there is no reason to expect a capsule to fail, but "no reason to expect" is not "shown."

The certifications. NSF Certified for Sport is a program, not a single test: an audited facility, finished-product verification of label claim and contaminants, and a 290-substance banned-list screen on production lots, with tested lots listed publicly. Mt. Angel's certificate is a document: the exact raw-material lot in your bottle, assayed by an independent laboratory, result and specification printed. They answer different questions. NSF answers "is this product clean and is the factory run properly." The lot certificate answers "was the active ingredient in this batch what it was supposed to be."

The price. $3.30 versus $1.50 per day. That is the largest single difference on the page, and it compounds: $216 over one four-month, trial-length course.

What is mostly marketing: the idea that a trademark means higher purity. Purity is a measurement. Timeline calls Mitopure highly pure, and the trial papers carry its record. Our raw-material lot assayed at 100% against a 98% minimum, and that number is printed on the certificate.

What the trials say

There is no head-to-head trial of Mitopure against any other urolithin A product, and none is registered that we could find. Everything below tested Mitopure. Every paper lists Amazentis employees among its authors, which is normal for a company that owns an ingredient and is also why an independent replication would matter. One does not exist yet.

Singh 2022, Cell Reports Medicine (randomized controlled trial). Eighty-eight sedentary, overweight adults aged 40 to 64 took 500 mg, 1,000 mg, or placebo daily for four months. Hamstring peak torque rose 12% at 500 mg (p = 0.027) and 9.8% at 1,000 mg (p = 0.029) against a placebo group that lost about 10%. The primary endpoint, peak power output on a cycle test, did not differ between groups. At 1,000 mg, six-minute walk distance rose 33 meters within group; plasma acylcarnitines fell at 500 mg and C-reactive protein at 1,000 mg. Limitation: a proof-of-concept study that missed its primary endpoint. The strength data are charted here.

Liu 2022, JAMA Network Open (randomized controlled trial). Sixty-six adults aged 65 to 90 took 1,000 mg or placebo daily for four months. Muscle endurance (contractions to fatigue in a hand and a leg muscle) improved at two months versus placebo. The two primary endpoints missed: six-minute walk distance and maximal ATP production in the hand muscle did not separate from placebo, and the placebo group also walked farther. Adverse events matched placebo. Limitation: small and demographically narrow (every participant was white, 76% were women).

Andreux 2019, Nature Metabolism (randomized controlled trial, phase 1). Sixty healthy, sedentary adults aged 61 to 85 took single ascending doses, then 36 of them took daily doses or placebo for 28 days (NCT02655393). Safety was the primary outcome; no signal. Urolithin A was bioavailable at every dose. At 500 and 1,000 mg, plasma acylcarnitines fell and mitochondrial gene expression in muscle biopsies rose. Limitation: biomarkers rather than function, over four weeks.

Singh 2021, European Journal of Clinical Nutrition (randomized, n = 100). One hundred healthy adults were randomized to a glass of pomegranate juice or a 500 mg urolithin A food product. Only 12% had detectable urolithin A at baseline. After the juice, about 40% converted the precursors into urolithin A. The 500 mg supplement produced more than six times the plasma exposure of the juice. Limitation: a single-dose bioavailability study, not an outcome trial.

Whitfield 2025, Sports Medicine (randomized controlled trial). Forty-two highly trained male distance runners took 1,000 mg or placebo for four weeks at altitude. A 3,000 m time trial did not improve in either group. Perceived exertion and creatine kinase after the time trial were lower with urolithin A, and muscle proteomics shifted toward mitochondrial pathways. Limitation: four weeks, elite men only, and the performance endpoint was null.

Evidence grades by outcome. Leg strength in sedentary adults 40 to 64 at 500 mg: Moderate (one RCT, primary endpoint missed). Muscle endurance in adults 65 to 90 at 1,000 mg: Preliminary. Plasma and muscle mitochondrial biomarkers: Moderate (consistent direction across three trials, inconsistent by dose). Performance in trained athletes: Insufficient (one null trial). Lifespan in humans: no data (the Ryu 2016 result is in worms).

What has not been tested. A non-Mitopure urolithin A product in any human trial. A hard capsule against a softgel, or anything longer than four months. Any trial without Amazentis on the author list. Amazentis has registered single-dose pharmacokinetic comparisons of urolithin A formulations on ClinicalTrials.gov (NCT06362018, for one), but we could find no published results. The 90-day rat toxicology (Heilman 2017) found no target organ at the highest dose fed, so the safety margin is wide while the efficacy record is four trials deep. For where dose stops paying off, see the dose-response analysis.

Who should pick which

If you are drug-tested in sport

Mitopure. NSF Certified for Sport is the certification USADA, MLB, and the NHL recognize, with a 290-substance banned-list screen on production lots. Mt. Angel's urolithin A is not in that program. This one is not close.

If you want the 500 mg trial dose at the lowest verified cost

Mt. Angel. One capsule, $1.50 a day, the same molecule and dose as the strength trial, with the raw-material lot assay published. You give up the trademark and the softgel. You keep $1.80 a day.

If you are 65 or older and considering the 1,000 mg protocol

Mt. Angel on cost, after a conversation with your clinician. The only trial in adults 65 to 90 used 1,000 mg a day, which is two capsules ($3.00) or four softgels ($6.60); over four months that is about $360 versus $792. Its primary endpoints missed, so keep expectations modest.

If you are a trained endurance athlete looking for a performance edge

Probably neither. The one trial in highly trained runners found no time-trial improvement after four weeks at 1,000 mg. Recovery markers moved. Performance did not. If drug testing applies to you, that decides it; otherwise wait for a longer trial.

If "clinically studied" on the label is the thing you are buying

Mitopure. Only one product can honestly print that, and it is theirs. We can print "the clinically studied dose." Different sentence.

Cost per effective day

Both products deliver 500 mg a day, so the math is list price divided by servings, read off each brand's own product page on October 14, 2026. Timeline's figure is its one-time list price; subscriptions will differ. Mt. Angel ships free over $75.

The gap is 2.2 to 1. Nothing in the trial data says a milligram of urolithin A from one factory does more than a milligram from another; nothing in the trial data tests it either. That is the whole comparison in one sentence.

A note on the one we make

We make Mt. Angel Vitamins Urolithin A at Highland Laboratories, our own cGMP facility in Mt. Angel, Oregon, operating under 21 CFR Part 111. Each capsule carries 500 mg of urolithin A to support mitochondrial renewal and cellular energy as part of a healthy-aging routine.* The exact raw-material lot in each batch is assayed by an independent laboratory, and that certificate is published by lot on our lab testing page so you can read the number rather than take our word for it. One capsule a day, 60 per bottle, $89.99.

See Mt. Angel Vitamins Urolithin A 500 mg

Timeline's Mitopure is not linked from this page; its facts were read from timeline.com on the date stated. For what each kind of certification and certificate does and does not prove, see our guide to supplement testing claims.

Next reads

• Urolithin A monograph: every trial graded by outcome.
• Urolithin A dose-response: where diminishing returns begin: why 500 mg is the default and what 1,000 mg buys.
• Best urolithin A supplements buying guide: the five-brand ranking, Timeline and Mt. Angel included.
• Urolithin A complete guide: the pillar, including food sources and who converts.

More on Urolithin A: The Complete Guide